Fig. 2

Summary of trends observed for the evolution of prions and other PAFs. The evolution of each prion/PAF is summarized. They are listed far right with prion gene names in bold, other PAFs in italics. Q-rich prions/PAFs are labeled with a green dot, N-rich with a red dot. Moving from right to left, we move deeper into the evolutionary past to a more ancient last common ancestor, and wider to more divergent clades of the fungi kingdom. First, we consider conservation in other Saccharomycetes, then in other Ascomycota beyond the Saccharomycetes, then finally in other Fungi beyond the Ascomycota. The fraction of orthologs with N/Q-rich domains in each of these groupings that are designated N-rich is listed. Where this is >0.5 the dot is red, otherwise it is green. At the bottom of these three columns is listed the overall fraction of N-rich