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Table 1 Summary of conservation of S. cerevisiae prion and PAF proteins in taxonomically defined sets of species*

From: Emergence and evolution of yeast prion and prion-like proteins

Conservation level**

Has ortholog

Has ortholog and N/Q-rich domain

Has ortholog and PLAAC prediction

Has ortholog and PAPA prediction

Has ortholog and PrionW prediction

Known Prions

 within Saccharomycetes

11/11

10

10

10

8

 within Ascomycota beyond Saccharomycetes

9

6

6

5

2

 beyond Ascomycota

9

6

6

5

2

Total set of PAFs

 within Saccharomycetes

27/27

26

26

26

21

 within Ascomycota beyond Saccharomycetes

20**

15

12

11

3

 beyond Ascomycota

18**

13

11

9

3

  1. *This table shows the fraction of the lists of prions and PAFs that are conserved in the taxonomic groups studied in this work. To be conserved ‘within Saccharomycetes’, a S. cerevisiae prion or PAF has to be found in any other Saccharomycetes species. To be conserved ‘within Ascomycota beyond Saccharomycetes’, a prion/PAF has to be found in any other Ascomycota species beyond the Saccharomycetes, and likewise for ‘beyond Ascomycota’. The columns denote the different cases simply an ortholog of the prion/PAF is detected, then an ortholog with an N/Q-rich domain, then an ortholog with a prion domain predicted by the PLAAC, PAPA or PrionW algorithms. This table includes the non-N/Q-rich prion former Mod5p
  2. **One classed as within Saccharomycetes only, has horizontal transfer (HT) to non-Saccharomycetes detected in the evolutionary tree. The prion-like domain in this cases post-dates the HT