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Fig. 5 | BMC Evolutionary Biology

Fig. 5

From: Binding interface change and cryptic variation in the evolution of protein-protein interactions

Fig. 5

The proportions of substitutions in interfaces between duplicate pairs where there is a conservation or divergence in physical interaction using the multiple confidence interaction set. The area of each circle represents the frequency of the substitution. Red circles show those substitutions that are present between duplicate interfaces where the interaction is conserved. Blue circles represent substitutions between duplicate interfaces where the interaction has diverged. As we do not have the ancestral sequence before duplication all substitutions are treated as undirected i.e. A to R is the same as R to A

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