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Fig. 6 | BMC Evolutionary Biology

Fig. 6

From: Binding interface change and cryptic variation in the evolution of protein-protein interactions

Fig. 6

Substitutions in interfaces of RNR4 and RNR2 that maintain an interaction with RNR4. Substitutions are shown in consecutive panels with RNR4 coloured gray with red side chains and the duplicate RNR2 shown in light blue with purple side chains. The interacting chains (in this case also RNR4) are shown in blue with yellow side chains. Coloured dots between chains represent atom contacts between the proteins detected by Probe. A substitution between a phenylalanine (Phe) on RNR4 (a) and a threonine (Thr) on RNR2 (b) maintains atom contacts with a lysine (Lys) on the interacting chain. A second substitution between a lysine (Lys) on RNR4 (c) and glutamic acid (Glu) on RNR2 (d) maintains atom contacts with a phenylalanine (Phe)

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