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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Functional test of PCDHB11, the most human-specific neuronal surface protein

Fig. 1

Pipeline for discovering human-specific amino acid substitutions. Amino acids in human proteins were considered human-specific wherever they differed from the consensus between the exomes of Macaca mulatta, Pongo abelii and Pan troglodytes. Differences were considered fixed if the human-specific amino acid recurred in 100 haploid human genomes. Among those proteins that could be aligned between the four genomes, the indicated number of proteins contains at least one fixed human-specific difference

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