Skip to main content

Table 2 Differences between non-human primate consensus and human PCDHB11

From: Functional test of PCDHB11, the most human-specific neuronal surface protein

Position

Consensus

Human

Weight

Domain

4

Glu

Gln

3

Signal peptide

106

Phe

Leu

5

EC1a

134

Leu

Ser

11

EC2a

185

Asn

Ile

12

EC2a

213

Thr

Ser

3

EC2a

252

Pro

Arg

10

EC3a

263

Thr

Ile

8

EC3a

281

Leu

Phe

5

EC3a

304

Thr

Arg

8

EC3a

334

Arg

Ile

12

EC3a

336

Gln

His

4

EC3a

724

Arg

Ser

8

Cytoplasmic

  1. Differences between modern human PCDHB11 and the consensus of Macaca mulatta, Pongo abelii and Pan troglodytes. Human is the consensus of 100 chromosomes, wherever it differs from the ancestral amino acid. Weight is derived from the evolutionary rate of exchange of each amino acid pair (for details see “Methods”). The table shows the amino acids in the constructs used in the experiments; current data show that there is indeed variation within modern humans at the signal peptide site. aEC1, EC2, EC3: extracellular cadherin domains 1–3