Fig. 5
From: GenFamClust: an accurate, synteny-aware and reliable homology inference algorithm
Cluster quality of various gene family inference methods on various families and the complete test data consisting of twenty families. The figure displays cluster quality of selected methods with default settings for various protein families as well as for twenty gene families in test data. Panels (a–d) display results for a particular protein family like FOX, TNFR, Kinase and USP respectively. FOX and TNFR are single domain architecture family while Kinase and USP have multidomain architecture with large sequence divergence and diverse domain architecture families. Panel (e) displays results for nineteen families (all except Kinases) because Kinases constitute more than half of proteins in number and could bias the overall results. Panel (f) displays the results for all twenty families. In all panels, GFC-based clustering methods have significantly higher or equal cluster quality than other methods