Skip to main content

Advertisement

Fig. 4 | BMC Evolutionary Biology

Fig. 4

From: Subfunctionalization of peroxisome proliferator response elements accounts for retention of duplicated fabp1 genes in zebrafish

Fig. 4

PPAR antagonism of zebrafish fabp1a and fabp1b.1 promoter activity was PPARα- and PPARγ-selective, respectively. Firefly luciferase activity driven by the fabp1a (a, b) or fabp1b.1 (c, d) promoters was normalized to Renilla luciferase activity driven by the TK promoter in HEK293A cells treated with 1 nM – 1 mM WY14643 (PPARα agonist) (a, c) or rosiglitazone (PPARγ agonist) (b, d) ± the PPAR antagonists 240 nM GW6471 (PPARα antagonist) or 10 nM T0070907 (PPARγ antagonist) for 24 h. Data are mean ± SD. *P < 0.001 compared to fabp1a/TK or fabp1b.1/TK alone as determined via one-way ANOVA followed by Bonferroni’s post-hoc test. n = 3

Back to article page