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Table 1 Individual HEV GI protein viral homologues

From: Ancient recombination events and the origins of hepatitis E virus

Protein

aClosest Hepeviridae homologue

E-value

Percent identity

1st-ranked Non-HEV viral homologue

Family/Genus

E- value

Percent identity

2nd-ranked Non-HEV viral homologue

Family/Genus

E- value

Percent identity

Polyprotein (ORF1) (NP056779)

Orthohepevirus C

0

57 %

bHelicoverpa armigera stunt virus (HASV)

Alphatetraviridae Omegatetravirus

1.74 × 10-262.03 × 10-7

26 % 29 %

bDendrolimus punctatus tetravirus

Alphatetraviridae/Omegatetravirus

1.28 × 10-21

7.42 × 10-8

7.42 × 10-8

25 %

25 %

20 %

Capsid (ORF2) (NP056788)

Orthohepevirus C

0

57 %

Porcine astrovirus

Astroviridae/Astrovirus

2.02 × 10-12

21 %

Chicken astrovirus

Astroviridae/Astrovirus

2.74 × 10-12

26 %

Phosphoprotein (ORF3) (NP056787)

None found

-

-

None found

-

-

-

None found

-

-

-

Methyltransferase (NP056780)

Orthohepevirus C

5.47 × 10-65

59 %

HASV

Alphatetraviridae Omegatetravirus

5.88 × 10-7

33 %

Frangipani mosaic virus

Virgaviridae/ Tobamovirus

6.50 × 10-6

30 %

Y domain (NP056781)

Orthohepevirus C

1.0 × 10-96

65 %

Hop latent virus

Betaflexiviridae Carlavirus

2.0 × 10-18

12 %

Blueberry scorch virus

Betaflexiviridae Carlavirus

6.0 × 10-18

12 %

PCP (Protease) (NP056782)

Orthohepevirus C

1.0 × 10-10

37 %

None found

-

-

-

None found

-

-

-

PPR (NP056783)

None found

-

-

None found

-

-

-

None found

-

-

-

Macro domain (X) (NP056784)

Orthohepevirus C

1.73 × 10-45

56 %

Aura virus

Togaviridae/ Alphavirus

4.61 × 10-8

36 %

Whataroa virus

Togaviridae/Alphavirus

5.95 × 10-8

36 %

Helicase (NP056785)

Orthohepevirus C

7.00 × 10-87

62 %

Turnip vein clearing virus

Virgaviridae/ Tobamovirus

6.04 × 10-13

31 %

Maracuja mosaic virus

Virgaviridae/ Tobamovirus

1.07 × 10-12

30 %

RdRp (NP056786)

Orthohepevirus C

3.64 × 10-177

59 %

Tick-borne tetravirus-like virus

Unclassified virus

7.82 × 10-20

33 %

Chara australis virus

Unclassified virus

2.98 × 10-11

34 %

  1. a Closest Hepeviridae homologue, excluding HEV taxonomic id (GenBank taxid #12161) sequences
  2. bHASV has two distinct homologous fragments; Dendrolimus punctatus tetravirus has three distinct homologous fragments to HEV GI polyprotein