Fig. 4

Preference for resistance using gene regulatory network (GRN) rewiring rather than protein mutations. The fraction of simulations where GRN rewiring strategy is used more often than protein binding site change for successful resistance under different protein binding complexities (Ls) and host receptor sequence mutation rates (μ _hp ). In a more complex receptor binding system, hosts tend to select the GRN rewiring strategy more often than the protein mutation strategy due to the single receptor targeting infection strategy. Since low μ _hp means a lower rate of protein mutations to counteract the rapidly evolving viruses, hosts tend to favor a protein mutation strategy less