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Fig. 9 | BMC Evolutionary Biology

Fig. 9

From: Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles

Fig. 9

Model for regulation and function of CYP26 genes in amphioxus. The position of the functionally validated retinoic acid response elements (RAREs) within the amphioxus CYP26 cluster is indicated relative to the start codons of the three amphioxus CYP26 genes (CYP26-1, CYP26-2, and CYP26-3). The relative expression of each of the genes is indicated during normal development (normal levels of RA and active RAR/RXR receptor heterodimers) as well as during exposure to RA (high levels of RA and active RAR/RXR receptor heterodimers), hence highlighting the dominance of CYP26-2 during normal development and the importance of CYP26-1 and CYP26-3 for protection against RA teratogenesis

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BMC Ecology and Evolution

ISSN: 2730-7182

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