Fig. 8

Statistics for the core TFBSs and their vicinity. a Distribution of lifetimes for the tracked TFBSs. b The within-generation distributions of the binding energy E of 85 core TFBSs shown for three different generations (analog of Fig. 5 a for the core sites). c Distribution of the regulatory rms-scores of TFBSs in the model (the strength of influence that a site exerts on gene expression) for the initial wild-type conditions, for five sets of TFBSs: core sites, non-core sites, all sites, sites cooperatively interacting with the core sites, and non-core sites overlapping with the core sites. d Distributions of lifetime for the neighbouring TFBSs (red) and for all except core binding sites (blue). The difference between the red and blue distributions are statistically significant under 5 percent level based on the bootstrapped KS test