Table 3 Association of G6PC2 variants with T2D
Sample/SNP (Variant) | Genotype frequency | Minor/Major allele | Minor allele freq (%) | Corrected p value | OR (IC 95%) | Corrected p value | OR (IC 95%) | ||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Unconditional | Conditional on rs560887 | ||
rs560887, intronic, (GWAS) | |||||||||
| Â | CC | CT | TT | Â | Â | Â | Â | Â | Â |
 Diabetic cohort | 0.643 | 0.319 | 0.038 | T/C | 19.7 | 0.368 | 1.23 (0.78–1.95) | - | - |
 Control cohort | 0.679 | 0.276 | 0.045 |  | 18.3 |  |  |  |  |
rs492594 (p.Val219Leu) | |||||||||
| Â | GG | GC | CC | Â | Â | Â | Â | Â | Â |
 Diabetic cohort | 0.334 | 0.475 | 0.19 | C/G | 42.9 | 0.099 | 1.50 (1.03–2.18) | 0.018 | 1.70 (1.14–2.54) |
 Control cohort | 0.368 | 0.483 | 0.149 |  | 39.1 |  |  |  |  |
rs2232328 (p.Ser342Cys) | |||||||||
| Â | CC | CG | GG | Â | Â | Â | Â | Â | Â |
 Diabetic cohort | 0.619 | 0.299 | 0.081 | G/C | 23.1 | 0.099 | 1.51 (0.97–2.36) | 0.034 | 1.64 (1.04–2.58) |
 Control cohort | 0.688 | 0.274 | 0.038 |  | 17.5 |  |  |  |  |