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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Evolutionary origin of type IV classical cadherins in arthropods

Fig. 2

Reconstruction of transcripts for type IVa and type IVb cadherins in pancrustaceans. a. Schematic representation of exons (upper, blue), coding sequences (middle, black), and domain organization (lower) of the type IVa DE-, Dp1-, and Ea1-cadherins from D. melanogaster, D. pulex, and E. affinis, respectively, and the type IVb Le1-, Ha1-, and Ph1-cadherins from L. exotica, H. azteca, and P. hawaiensis, respectively. The scale bar indicates 600 bp. Breaks in the black lines indicate gaps in the amino acid sequence alignment of the five cadherins (Additional file 4: Figure S3). The domain names are abbreviated as follows: EC, extracellular cadherin domain; NC, non-chordate classical cadherin domain; CE, cysteine-rich EGF-like domain; LG, laminin globular-like domain; TM, transmembrane domain; CP, cytoplasmic domain. Asterisks indicate transcript regions with sequences that were not (black) or only partially (gray) found in the WGS reads. b. Capability of Le1-cadherin to mediate cell aggregation. Drosophila S2 cells transiently transfected with empty pUAST (left) or pUAST-Le1-cadherin (right) in combination with pUAST-mKate2 and pWA-GAL4 were used for the cell aggregation assay. Cells expressing the exogenous genes were identified via mKate2 fluorescence (red). Scale bar, 50 μm

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