Fig. 4

Blast-based dot-plot comparisons between the amino acid sequence of Le1-cadherin and those of other classical cadherins. The classical cadherins analyzed are as follows: type IVb Le1-cadherin (Le1, sea slater); type IVa DE-cadherin (DE, fruit fly); type IVa Dp1-cadherin (Dp1, water flea); Sm1-cadherin (Sm1, centipede); type III Cm-cadherin (Cm, shrimp); type III Le2-cadherin (Le2, sea slater); type III DN-cadherin (DN, fruit fly); type III Pn-cadherin (Pn, fish). Green boxes indicate comparisons between the EC1-EC5 region of Le1-cadherin and the EC6-EC10 regions of the type III cadherins or the corresponding region of Sm1-cadherin, which exhibited marked collinear similarities. Note that the EC1 domain of Sm1-cadherin appears to be divergent. Blue boxes indicate comparisons between the EC6-EC8 region of Le1-cadherin and the EC11-EC16 regions of the type III cadherins or the corresponding region of Sm1-cadherin, which exhibited ambiguous collinear similarities. Note that strong specific signals for collinear similarities were detected between the EC6-EC8 regions of Le1- and Sm1-cadherins