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Table 1 Description of the wild house mice populations used in this study

From: Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice

Population Species Location Study Sample Size RIIIS/J Allele Frequency Hardy-Weinberg
ID Group RR RC CC Total
 DE A Mmd Cologne-Bohn (DE) i 0 0 36 36 0.00 Equilibrium
 CB A Mmd Cologne-Bohn (DE) iii 0 0 15 15 0.00 Equilibrium
 DB A Mmd Divonne-lès-Bains (FR) iii 0 1 11 12 0.04 Equilibrium
 LO A Mmd Louan-Villegruis-Fontaine (FR) iii 0 0 12 12 0.00 Equilibrium
 NA A Mmd Nancy (FR) iii 0 0 12 12 0.00 Equilibrium
 SL A Mmd Schömberg (DE) iii 0 1 11 12 0.04 Equilibrium
Overall A -- -- -- 0 2 97 99 0.01 Equilibrium
 MC B Mmd Massif Central (FR) iii 1 11 7 19 0.34 Equilibrium
 ES B Mmd Espelette (FR) iii 3 10 9 22 0.36 Equilibrium
 AN B Mmd Anger (FR) iii 4 8 6 18 0.44 Equilibrium
 CH B Mmd Chicago (USA) i 1 3 6 10 0.25 Equilibrium
 CA B Mmd Cameroon i 2 18 9 29 0.38 Equilibrium
 FR B Mmd Massif Central (FR) i 12 16 22 50 0.40 Homozygotes Excess
Overall B -- -- -- 23 66 59 148 0.38 Equilibrium
 IR C Mmd Iran ii 10 5 2 17 0.74 Equilibrium
 SP C Ms Spain ii 19 7 1 27 0.83 Equilibrium
Overall C -- -- -- 29 12 3 44 0.80 Equilibrium
  1. Data from populations belonging to Mus musculus domesticus (Mmd) or Mus spretus (Ms) were included from (i) Johnsen et al. 2009 [4], (ii) Linnenbrink et al. 2011 [5] and (iii) Linnenbrink 2013 et al. [18]. The populations are categorized into three groups: A) populations with low RIIIS/J allele frequency, suspected to be in a non-pathogenic environment, B) populations with intermediate RIIIS/J allele frequency, suspected to be in a pathogenic environment and C) populations with high frequency of a modified RIIIS/J allele assumed to carry no bleeding cost, and suspected to be in a pathogenic environment. The sample size is given with the number of individuals of each genotype (RR for RIIIS/J homozygotes, CC for C57BL/6 J homozygotes and RC for heterozygotes), and the total number of mice. The corresponding RIIIS/J allele frequency and whether the population significantly deviates from HWE are also indicated