Table 1 Functional groups of genes/proteins (datasets) that were included into the catalog of genes involved in response to TBEV infection

1.

Physical interaction

(Additional file 1: Table S1)

Genes encoding proteins that had direct physical interactions with TBE viral particle, TBEV proteins or RNA.

2.

Up- or down-regulated

(Additional file 1: Table S2)

Genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection^a

3.

Allelic variant

(Additional file 1: Table S3)

Allelic variant in this gene was associated with susceptibility or resistance to TBEV infection^b

4.

Increased/attenuated antiviral activity

(Additional file 1: Table S4)

These proteins were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity

5.

Knockout

(Additional file 1: Table S5)

Knockout of these genes in mice increased mortality rates or affected the other clinical manifestations of the disease

All_catalog

(Additional file 1: Table S6)

The catalog of human genes involved in response to TBEV infection.