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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Resource competition promotes tumour expansion in experimentally evolved cancer

Fig. 1

Spheroid spread over time. a. Images of MCF7 cell populations demonstrating differences in spheroid (in vitro tumours of approximately 1000 cells) spread over a 72-h period. Cell motility was calculated by measuring the change in surface area covered by spheroids over time; b Average spheroid spread (across 3 replicate lines) for selection lines under high and low resource supply over 12 weekly transfers. Spreading was measured 72 h after adhesion of the spheroid, and in the selective environment for each line (i.e. the motility of the low resource supply line was measured in low resource medium). Closed circles represent lines evolved under low resources, open circles are lines evolved with access to high resources. Areas are square-root transformed (± 1 SE)

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