Evolution of CYP2J19, a gene involved in colour vision and red coloration in birds: positive selection in the face of conservation and pleiotropy

Table 2 Site-specific analysis of CYP2J19 for 43 avian species in PAML

Model	Parameter estimates	lnL	Model comparison	LRT Statistic	df	P-value	Positively selected sites under BEB P > 95% (bold: P > 99%)
M0	ω₀ = 0.147	−12,990.709
M1a	ω₀ = 0.056 p₀ = 0.868 ω₁ = 1.000 p₁ = 0.132	−12,561.580
M2a	ω₀ = 0.056 p₀ = 0.868 ω₁ = 1.000 p₁ = 0.077 ω₂ = 1.000 p₂ = 0.055	−12,561.580	M1a vs. M2a	0.000	2	1.000
M7	p = 0.168 q = 0.788	− 12,533.632
M8	p₀ = 0.935 (p₁ = 0.065) p = 0.302 q = 2.898 ω_s = 1.383	−12,502.845	M7 vs. M8	61.574	2	0.000*	37, 122, 329, 455, 474

Underlined sites fall within predicted functional domains for CYP2 proteins annotated in Almeida et al. 2016 [22]
*Significant result at p < 0.01

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