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Fig. 8 | BMC Evolutionary Biology

Fig. 8

From: Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa

Fig. 8

Alternative Splicing of GNAO. a The Vertebrata GNAO gene has two transcripts (.1 light blue and .2 cyan) that arise from mutually exclusive splicing of its final exon pair: exon7 and 8. Note that exon lengths correlate with box lengths while lines do not correlate with intron size. b Tertiary structural model of the heterotrimeric G protein. Gαo (blue) and the heterotrimer Gβγ subunits (crimson/grey) coupled to a GPCR (pink). The two mutually exclusive exons encode regions necessary for coupling to active GPCRs and subsequently activating the G protein itself. The differences in sequences may influence coupling affinity and activation efficiency

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