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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Fig. 3

Adaptation to normoxia (N) is accompanied by an evolutionary trade-off which is supressed by cysteine under CoCl2 mimicked hypoxia (H) in ES2 cells. Cell death levels in a drug-free environment for a. and b. ES2 cells and c. and d. OVCAR3 cells. N selected – cells selected under normoxia; H selected – cells selected under CoCl2 mimicked hypoxia; N – Normoxia; NC – Normoxia supplemented with cysteine; H – CoCl2 mimicked hypoxia; HC – CoCl2 mimicked hypoxia supplemented with cysteine. Results are shown as mean ± SD. In a. and c. asterisks represent statistical significance compared to cells cultured under normoxia within each cell line. Cardinals (#) represent statistical significance of cells cultured in CoCl2 mimicked hypoxia with cysteine compared to cells cultured under CoCl2 mimicked hypoxia without cysteine within each cell line. In b. and d. asterisks represent statistical significance among cell lines within each treatment. *p < 0.05, **p < 0.01, ***p < 0.001 or #p < 0.05, ##p < 0.01, ###p < 0.001 (One-way ANOVA with post hoc Tukey tests)

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