Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Table 6 ES2 and OVCAR3 cells dynamics of response to carboplatin

A.
Treatments – cell death analysis - 16 h vs 24 h vs 48 h	Tukey test sig.
ES2-AN 16 h vs 48 h	0.014
ES2-ANC 16 h vs 48 h	0.000
ES2-ANC 24 h vs 48 h	0.000
ES2-AH 16 h vs 24 h	0.006
ES2-AH 24 h vs 48 h	0.001
ES2-AHC 16 h vs 24 h	0.007
ES2-AHC 16 h vs 48 h	0.000
ES2-AHC 24 h vs 48 h	0.000
OVCAR3-AN 16 h vs 48 h	0.000
OVCAR3-AN 24 h vs 48 h	0.000
OVCAR3-ANC 16 h vs 48 h	0.000
OVCAR3-ANC 24 h vs 48 h	0.000
OVCAR3-AH 16 h vs 48 h	0.000
OVCAR3-AH 24 h vs 48 h	0.000
OVCAR3-AHC 16 h vs 48 h	0.000
OVCAR3-AHC 24 h vs 48 h	0.000
B.
Treatments – cell death analysis - 16 h vs 24 h vs 48 h	Tukey test sig.
ES2-NN 16 h vs 48 h	0.000
ES2-NN 24 h vs 48 h	0.001
ES2-NNC 16 h vs 48 h	0.000
ES2-NNC 24 h vs 48 h	0.000
ES2-NHC 16 h vs 48 h	0.001
ES2-NHC 24 h vs 48 h	0.002
OVCAR3-NN 16 h vs 48 h	0.000
OVCAR3-NN 24 h vs 48 h	0.000
OVCAR3-NNC 16 h vs 24 h	0.041
OVCAR3-NNC 16 h vs 48 h	0.001
OVCAR3-NNC 24 h vs 48 h	0.01
OVCAR3-NH 16 h vs 48 h	0.002
OVCAR3-NH 24 h vs 48 h	0.006
OVCAR3-NHC 16 h vs 48 h	0.000
OVCAR3-NHC 24 h vs 48 h	0.001
C.
Treatments – cell death analysis - 16 h vs 24 h vs 48 h	Tukey test sig.
ES2-HH 16 h vs 48 h	0.048
ES2-HH 24 h vs 48 h	0.043
OVCAR3-HN 16 h vs 48 h	0.000
OVCAR3-HN 24 h vs 48 h	0.000
OVCAR3-HNC 16 h vs 48 h	0.000
OVCAR3-HNC 24 h vs 48 h	0.000
OVCAR3-HH 16 h vs 48 h	0.000
OVCAR3-HH 24 h vs 48 h	0.000
OVCAR3-HHC 16 h vs 48 h	0.001
OVCAR3-HHC 24 h vs 48 h	0.002

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