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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution

Fig. 1

The ribosomal oxygenases (ROXs) are a subgroup of Fe(II) and 2OG-dependent oxygenases that modify the ribosome and are present in pro- and eukaryotes. a The human ROXs RIOX2/MINA53 and RIOX1/NO66 hydroxylate histidine residues in the ribosomal proteins RPL27A and RPL8, respectively, whereas (b) the E.coli ycfD protein hydroxlyates an arginine in Rpl16 [6]. Protein sequence and crystal structure analyses confirmed a similar protein-domain architecture for the three proteins [16]. c They consist of a JmjC-domain (red), a dimerization domain (brown) for homo-oligomerization and a winged-helix (WH) domain (blue). The aa triad HxD…H that coordinates the iron and is essential for catalytic activity is indicated in green (c)

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