Fig. 5

Proposed evolution of the EPDR family. The presence of EPDR sequences in particular groups is indicated by blue boxes, and the evolutionary origin of major EPDR clades is depicted by solid bars. The unikont ancestor likely possessed both clade 1 and clade 2 EPDRs, however it is possible that clade 1 EPDRs arose later, in the opisthokont ancestor. Major expansion of EPDR genes occurred in lineages indicated by an asterisk