Fig. 5

Functional tree of the A-locus. Unrooted UPGMA tree showing the functional clustering of all reported A molecules for bonobos and chimpanzees, as well as all reported A-like molecules for chimpanzees. This tree was produced by using MHCcluster 2.0, R (version 3.1.3) with the package ape (version 3.4) and Inkscape (version 0.92). Close clustering of MHC molecules indicates a similar peptide binding repertoire of the MHC molecules. Bootstrap values at the split points of individual MHC molecules are indicated by red dots, thereby large dots indicate a bootstrap value larger than 0.95, medium dots indicate a bootstrap value between 0.85 and 0.95, and small dots indicate a bootstrap value lower than 0.85. The maximum possible bootstrap value is 1. A bonobo specific cluster and the A-like sequences are designated