Fig. 1
From: Origin and diversification of the plasminogen activation system among chordates
Phylogenetic relationship and protein domain composition of the human serine protease members of the plasminogen activation system and their close paralogues. a PLG-group and b PLG activators group members. PLG (plasminogen), HGF (hepatocyte growth factor), MST-1 (macrophage stimulating 1), HABP2 (hyaluronan binding protein 2), LPA (lipoprotein a), HGFAC (hepatocyte growth factor activator), tPA (tissue-type plasminogen activator) and uPA (urokinase-type plasminogen activator). (*) Members of PAS in mammals. Domain composition: FN1 (fibronectin type 1), FN2 (fibronectin type 2), K (kringle), EGF (epidermal growth factor), PAN (PAN/APPLE), T (trypsin). Phylogenetic tree derived from the human phylome from PhylomeDB [36]