Fig. 6
From: Origin and diversification of the plasminogen activation system among chordates
Phylogenetic relationship serpin V3 members and PAI-2. Maximum-likelihood tree rooted at SPN-1 Nematostella vectensis (XP_001627732.1). Percentage of bootstrap support after 1000 replicates shown in the branches. Asterisks (**) indicate the location of reciprocal best hits to human PAI-1 and SERPINI1 in urochordates. PAI-1/SERPINE1 (plasminogen activator inhibitor-1/serpin E1), SERPINE3 (serpin E3), SERPINI1 (serpin I1), SERPINE3 (serpin E3), PAI-2 (plasminogen activator inhibitor-2, placental type). The unrooted tree is provided in Additional file 4