Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales

Springer, Mark S.; Emerling, Christopher A.; Gatesy, John; Randall, Jason; Collin, Matthew A.; Hecker, Nikolai; Hiller, Michael; Delsuc, Frédéric

doi:10.1186/s12862-019-1359-6

Table 1 Inactivating mutations and whole exon deletions in the ODAM gene of toothless, enamelless, and other placental mammals

From: Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales

Taxon	Exon 1	Exon 2	Exon 3	Exon 4	Exon 5	Exon 6	Exon 7	Exon 8	Exon 9	Exon 10	Splice site mutations^a
Orycteropus			123-125S	256I, 348D					1081I	1139-1141S	In3Do (AT)
Vermilingua									790-792S
Tamandua tetradactyla	29I		105D	306-308S, 336I, 374-375D	430D	546-548S, 573-575S	668-670S	707-713D	797-799S, 1103-1112D		In2Do (AT)
Cyclopes didactylus			127D				671I	NRM		NRM	In1Ac (AT), In4Do (GG), In6Do (AT), In7Do (AT)
Choloepus								745-754D
Choloepus hoffmanni				400-402S
Choloepus didactylus		NBR								NBR
Dasypus novemcinctus			138-140S	400-402S		606-608S			1127-1129S
Chlamyphoridae		93-98D^b
Chaetophractus vellerosus							672-674S		820D		In9Ac (CG)
Cabassous + Calyptophractus											In4Ac (TG)^c
Tolypeutinae			144-146S			570-573D					In6Ac (AA), In9Ac (AA)
Tolypeutes matacus	1-3SCD				NBR		672-674S				In8Do (TT)
Cabassous unicinctus						595-598D		NBR	NBR
Chlamyphorus truncatus	NRM	NRM	NRM	NRM	NRM		672-674S				In8Do (RT)
Calyptophractus retusus									1092D
Manis				195D, 265-268D, 345D		518D, 561D	657-658I, 672-674S	687I	1088D		In4Do (AT), In5Do (CT), In6Do (CT)
Manis pentadactyla			123-125S	203I
Manis javanica				350D					851-1059I		In9Do (AC)
Balaenidae				420D
Eubalaena glacialis											In6Do (AT)
Balaenopteroidea											In2Do (AT)
Eschrichtius robustus + Balaenoptera acutorostrata + B. bonaerensis + B. borealis						513-515S
Balaenoptera acutorostrata + B. bonaerensis				263D
Balaenoptera bonaerensis				382-384S
Balaenoptera borealis										1159-1165D^d
Physeter macrocephalus											In4Do (AT)
Lipotes vexillifer				195-197S, 264-266S, 288-290S
Delphinidae + Monodontidae + Phocoenidae				232I, 424-425I
Phocoenidae									793I
Phocoena phocoena											In2Ac (AT)
Tursiops truncatus									793I
Neomonachus schauninslandi			104-105D	198-200S	429-479D						In2Ac (AA)
Callithrix jacchus					477-479S						In4Ac (AC)

^aMutated splice sites are shown in parentheses
^bDeletion includes last six bp of exon 2 and first nine bp of intron 2 including donor splice site
^cNo blast results for Chlamyphorus and Tolypeutes
^dEight bp deletion that includes stop codon
Abbreviations: Ac acceptor splice site, D frameshift deletion, Do donor splice site, I frameshift insertion, In intron, NBR no blast results, NRM no reads mapped, S premature stop codon relative to original reading frame, SCM start codon mutation
Position numbers correspond to the complete protein-coding alignment for 165 placental mammals

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ISSN: 2730-7182

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