Table 1 Functional enrichment summary of protein-protein interaction network of proteins evolved with accelerated RSA change rate in Primata clade (based on STRING [54] data; see Fig. 6)
Function | Heterotachy model | Heterotachy and Site partitioning models intersection, all data | ||||
|---|---|---|---|---|---|---|
All data | Protein structure-aware data | |||||
FDR | Colora | FDR | Colora | FDR | Colora | |
fatty acid beta-oxidation | 0.0001 | – | 3.9E-05 | blue | 0.0493 | blue |
oxidation-reduction process | 1.9E-08 | red | 3.9E-05 | yellow | 0.0106 | red |
mitochondrion organization | 4.1E-05 | violet | 0.0002 | – | 0.0493 | green |
carboxylic acid catabolism | 0.0003 | – | 3.9E-05 | green | 0.0493 | yellow |
carboxylic acid metabolism | 3.9E-06 | yellow | 2.3E-05 | red | – | – |
single-organism metabolism | 2.4E-07 | blue | 9.0E-05 | violet | – | – |
small molecule metabolism | 0.001 | – | 0.0002 | – | – | – |
α-amino acid metabolism | 0.009 | – | 0.0015 | – | – | – |
cellular respiration | 1.0E-06 | green | – | – | – | – |
negative regulation of RIG-I signaling | 0.0102 | – | – | – | – | – |
mitochondrial transport | 0.015 | – | – | – | – | – |