Table 2 Functional enrichment summary of protein-protein interaction network of proteins evolved with accelerated RSA change rate in Primata clade (based on GENEMANIA [55] data; see Fig. 6)

carboxylic acid catabolism

0.000188

2.53E-12

0.000269

organic acid catabolism

0.000188

2.53E-12

0.000269

small molecule catabolism

0.000812

2.32E-11

0.000768

fatty acid beta-oxidation

0.000812

1.46E-11

0.004036

alpha-amino acid metabolism

0.000888

0.000142

0.008642

monocarboxylic acid catabolism

0.00394

1.46E-11

0.009869

mitochondrial matrix

1.37E-14

3.24E-18

–

mitochondrial nucleoid

9E-06

6.57E-07

–

mitochondrial membrane

2.82E-06

9.28E-06

–

water-soluble vitamin metabolism

0.000812

4.74E-06

–

cellular respiration

5.87E-07

–

0.001263

mitochondrial inner membrane

0.000888

0.00178

–

carnitine transmembrane transport

–

0.003698

0.004036

amino-acid betaine transport

–

0.004428

0.004036

carnitine transport

–

0.004428

0.004036

cofactor metabolism

0.002887

0.006798

–

fatty acid transmembrane transport

–

0.005223

0.004663

quaternary ammonium group transport

–

0.00747

0.006053