Table 7 Functional enrichment summary of protein-protein interaction network of proteins evolved with decelerated RSA changes rate in Primata clade Functional enrichment summary (based on GENEMANIA [55] data)

mitochondrial matrix

7.41E-25

1.85E-20

cellular respiration

7.41E-25

6.65E-20

energy derivation by oxidation of organic compounds

1.18E-20

1.15E-16

mitochondrial inner membrane

3.40E-18

1.28E-15

respiratory electron transport chain

6.77E-16

6.00E-11

hydrogen ion transmembrane transport

1.26E-06

1.20E-10

tricarboxylic acid cycle

1.85E-08

1.47E-06

aerobic respiration

3.07E-07

1.44E-05

oxidoreductase complex

1.70E-10

–

mitochondrial electron transport, NADH to ubiquinone

1.07E-06

–

mitochondrial respiratory chain comp. I

1.26E-06

–

mitochondrial ATP synthesis coupled electron transport

1.73E-06

–

oxidoreductase activity, acting on NAD(P)H, quinone or similar as acceptor

3.86E-06

–

regulation of acetyl-CoA biosynthesis from pyruvate

1.10E-05

–