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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

Fig. 3

Structural deviations between human wild type and mutated FZD4 structures. Major structural shifts caused by disease associated missense mutations of the FZD4 protein were observed in the K-S/T-XXX-W and T/S-X-V PDZ binding motifs present in the carboxyl-terminal region. Mutated residues are labeled in red. a Represents the structure of wild type FZD4 protein in which all domains and motifs are color coded. b Shows structural superposition of wild type FZD4 (green) and mutated model G36D (coral peach). c Depicts structural comparison between wild type FZD4 (green) and mutated model C204R (coral peach). d Represents the structural deviations among wild type FZD4 (green) and mutated model G488D (coral peach)

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BMC Ecology and Evolution

ISSN: 2730-7182

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