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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: The first identification of complete Eph-ephrin signalling in ctenophores and sponges reveals a role for neofunctionalization in the emergence of signalling domains

Fig. 1

Presence and absence of Eph (receptor) and Ephrin (ligand) pairs in eukaryotes. a Schematic representation of ephrin ligand and Eph receptor protein domain architectures. Ephrin A and B ligands are depicted extending from a cell on the left, and Eph-A and -B receptors are extending from a cell on the right. A forward signal emanates from Eph receptors and a negative signal emanates from the ephrin ligands. CRD, Cysteine Rich Domain; fn3, fibronectin domain; GPA, GlycoPhosphatidylinositol (GPI)- linked Anchor; kinase, tyrosine kinase; LBD, Ligand Binding Domain; P, Phosophorylation sites; PDZ, Post synaptic density protein/Disc large tumor suppressor/Zonula occludens-1 domain; RBD, Receptor Binding Domain; SAM, Sterile Alpha Motif; TM, single-pass TransMembrane domain. b Heat map showing the number of Eph and ephrin genes detected in each of the sampled genomes and transcriptomes. Absolute counts of proteins used to plot the heap map are provided in Additional file 1: Table S2. c Number of genes detected in genomes and transcriptomes of ctenophore and sponge species. Homos., Homoscleromorpha; Calc., Calacarea. Shades of blue denote presence/counts, while grey boxes denote absence. Eph (FL), Full Length Ephrin receptor

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