Fig. 2

The human genes duplicated in parallel lie in respective co-duplicated groups. Consistencies in phylogenetic tree topologies of families (analyzed in this and our previous study) with at least threefold representation on human tetra-paralogon Hsa1/2/8/20 (a) Schematic topology of MROH and STK families; b schematic topology of E2F, EYA and STMN families; c schematic topology of HCK, DLGAP, NKAIN, KCNQ and MATN gene families; d schematic topology of FAM110, NCO, KCNS, YTHDF, XKR and MYT gene families. For each case, the percentage bootstrap values of internal branches are provided in parentheses except for gene families exhibiting slightly lower bootstrap values (≤50%).The connecting bars on the left portray the close physical associations of relevant genes. Asterisk symbol * designate the relevant chromosomes