Skip to main content
Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants

Fig. 3

Evolutionary phylogenetic timetree representing evolution in extant vertebrate species showing the emergence of ADGRL4/ELTD1 variants. Red terminal nodes indicate ADGRL4/ELTD1 variant 1; blue terminal nodes indicate ADGRL4/ELTD1 variant 2; and the white circles indicate the low frequency ADGRL4/ELTD1 variant 3. Blue phylogenetic lines indicate the emergence of ADGRL4/ELTD1 variant 2 expression according to the model. The earliest vertebrates to encode ADGRL4/ELTD1 variant 2 were the three included mammals from the Afrotheria group (hyrax, elephant and lesser hedgehog) diverging from their common ADGRL4/ELTD1 variant 1 encoding ancestor approximately 101 million years ago. * indicates animals which express both ADGRL4/ELTD1 variant 1 and 2 according to NCBI RefSeq or Ensembl. ** indicates animals which expresses all three ADGRL4/ELTD1 variants (only duck in this data set)

Back to article page