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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species

Fig. 1

I-TASSER predicted M. musculus HWAK (NP_848862.1; panels a and b) and HWGK GULO (panels c and d) models. For the HWAK GULO model, in a), we can identify an open channel in the protein structure, leading to the exposed HWAK motif (red) and the adjacent Glu-Arg pair (magenta). Furthermore, we can also identify the FAD-binding motif at the surface (yellow). In b), we can identify the surface contact point between the HWAK (red) and FAD-binding (yellow) motifs. As for the HWGK GULO model, in c), we can observe the single protein surface point were the Glu-Arg pair is located (magenta). In d), we can see the two exposure points of the conserved FAD-binding domain

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