Table 2 Gene level mutations and the boundary conditions
Parameter | Gene types | Value range in simulation |
|---|---|---|
Promoter strength | Enzyme, transporter, TF | [0.001,10] |
K substrate | Enzyme, transporter | [0.001,10] |
K energy | Transporter | [0.001,10] |
K ligand | TF | [0.001,10] |
K operator | TF | [0.001,10] |
V max | Enzyme, Transporter | [0.001,10] |
effect-bound | TF | [0.001,10] |
effect-apo | TF | [0.001,10] |
ligand | TF | A, B, C, or e |
exporting | Transporter | True,False |
sense-external | TF | [True,False] |
binding-motif | TF | bit flip at random position |
operator-sequence | Enzyme, Transporter, TF | bit flip at random position |