Table 4 Selected DEG in Set C for waveform duration by “general” functional class and EOD phenotype, and highlights of their predicted function
From: The transcriptional correlates of divergent electric organ discharges in Paramormyrops electric fish
NCBI Gene ID | Gene Description | Gene Symbol | “general” functional class | upregulated in phenotype | Highlights of Predicted Function (edited from UniProt) |
|---|---|---|---|---|---|
111834716 | Kv channel-interacting protein 4 | LOC111834716 | Cation homeostasis | short EODs | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner |
111836747 | potassium channel subfamily K member 5-like | LOC111836747 | Cation homeostasis | short EODs | pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations |
111857989 | chloride intracellular channel protein 5-like | LOC111857989 | Cation homeostasis | short EODs | Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion |
111833088 | myosin-7-like | LOC111833088 | Cytoskeletal & sarcomeric | long EODs | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction |
111856289 | pleckstrin homology-like domain family B member 1 | LOC111856289 | Cytoskeletal & sarcomeric | long EODs | GO BP: regulation of microtubule cytoskeleton organization |
111842483 | parvalbumin-2 | LOC111842483 | Cytoskeletal & sarcomeric | short EODs | In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions |
111846153 | troponin I, slow skeletal muscle-like | LOC111846153 | Cytoskeletal & sarcomeric | short EODs | Inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity |
111851695 | keratin, type II cytoskeletal 8-like | LOC111851695 | Cytoskeletal & sarcomeric | short EODs | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle |
111856036 | parvalbumin-2-like | LOC111856036 | Cytoskeletal & sarcomeric | short EODs | In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions |
111860236 | tropomyosin alpha-1 chain-like | LOC111860236 | Cytoskeletal & sarcomeric | short EODs | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
111845490 | matrilin 2 | matn2 | Extracellular matrix | long EODs | Involved in matrix assembly |
111860169 | thrombospondin-4-like | LOC111860169 | Extracellular matrix | long EODs | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment |
111860877 | collagenase 3-like | LOC111860877 | Extracellular matrix | short EODs | Plays a role in the degradation of extracellular matrix proteins |
111834720 | protein EFR3 homolog B-like | LOC111834720 | Lipid metabolism | short EODs | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis |
111840357 | PTB domain-containing engulfment adapter protein 1-like | LOC111840357 | Lipid metabolism | short EODs | Modulates cellular glycosphingolipid and cholesterol transport |
111846286 | retinoic acid receptor responder protein 3-like | LOC111846286 | Lipid metabolism | short EODs | Catalyzes the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) |
111847640 | phosphatidylinositol 3-kinase regulatory subunit gamma-like | LOC111847640 | Lipid metabolism | short EODs | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity |
111852373 | proto-oncogene c-Fos-like | LOC111852373 | Lipid metabolism | short EODs | In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A |
111857713 | HRAS-like suppressor 3 | LOC111857713 | Lipid metabolism | short EODs | Catalyzes the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) |
111860935 | fatty aldehyde dehydrogenase-like | LOC111860935 | Lipid metabolism | short EODs | Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids |