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Table 6 Selected DEG in Set C for waveform complexity, by “general” functional class and EOD phenotype, and highlights of their expected function

From: The transcriptional correlates of divergent electric organ discharges in Paramormyrops electric fish

NCBI Gene ID

Gene Description

Gene Symbol

“general” functional class

upregulated in phenotype

Highlights of Predicted Function (edited from UniProt)

111838181

solute carrier family 9 member A7

slc9a7

Cation homeostasis

Biphasic

Protein: Sodium/hydrogen exchanger 7. Gene: SLC9A7. Mediates electroneutral exchange of protons for Na + and K+ across endomembranes

111848312

voltage-dependent calcium channel gamma-1 subunit-like

LOC111848312

Cation homeostasis

Triphasic

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics

111841270

family with sequence similarity 110 member C

fam110c

Cytoskeletal & sarcomeric

Biphasic

May play a role in microtubule organization

111845832

5′-AMP-activated protein kinase subunit gamma-2-like

LOC111845832

Cytoskeletal & sarcomeric

Biphasic

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK). Acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin

111850616

transmembrane protein 47-like

LOC111850616

Cytoskeletal & sarcomeric

Biphasic

Regulates cell junction organization in epithelial cells. May regulate F-actin polymerization

111851223

FYVE, RhoGEF and PH domain-containing protein 4-like

LOC111851223

Cytoskeletal & sarcomeric

Biphasic

Plays a role in regulating the actin cytoskeleton and cell shape

111857398

protein-methionine sulfoxide oxidase mical2b-like

LOC111857398

Cytoskeletal & sarcomeric

Biphasic

Promotes depolymerization of F-actin

111857697

leiomodin 2

lmod2

Cytoskeletal & sarcomeric

Biphasic

Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function

111854588

capping protein regulator and myosin 1 linker 3

carmil3

Cytoskeletal & sarcomeric

Triphasic

No info for CARMIL3, but CARMIL2 is a cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Enhances actin polymerization

111841398

inter-alpha-trypsin inhibitor heavy chain 3

itih3

Extracellular matrix

Biphasic

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix proteins

111841399

inter-alpha-trypsin inhibitor heavy chain H3-like

LOC111841399

Extracellular matrix

Biphasic

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix proteins

111853010

ependymin-like

LOC111853010

Extracellular matrix

Triphasic

GO MF: calcium ion binding. GO BP: cell-matrix adhesion

111853814

epiphycan-like

LOC111853814

Extracellular matrix

Triphasic

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization

  1. BP biological process, DEG differentially expressed genes, EOD electric organ discharge, GO gene ontology, MF molecular function, NCBI National Center for Biotechnology Information