Fig. 2

Amy2b haplotypes and distribution patterns. a Depiction of the disabling mutation in exon 1 of Amy2b and list of inbred mouse strains that carry either of the variants. The sequence shown corresponds to positions chr3:113,156,570-113,156,584 in the mm10 genome reference sequence. b Frequencies and distribution of the disabling (T-allele) versus enabling (C-allele) in additional different M. m. domesticus populations in France and Germany taken from [25]. c Native gel of pancreas samples stained with amylase activity assay for four animals each of the indicated populations. The Ger population displays an array of three different variants, each with lower activity. Note that a denaturing gel would not resolve these variants (data not shown). The Fra and Kaz animals show only one variant with strong activity