Table 2 Common features in the proximity of tyrosine sulfation sites
Feature | Position from Tyr (Y) | Description |
|---|---|---|
Prevalence of acidic residues | ±5 | Presence of several Glu (E) or Asp (D) residues near the Tyr (Y). Frequently at the − 1 position. |
Prevalence of turn-inducing residues | ±7 | Several Pro (P), Gly (G), Asn (N), Asp (D) or Ser (S) residues present within seven residues of the Tyr (Y). |
Limited basic and hydrophobic residues | ±5 | Only few Arg (R), Lys (K), His (H), Phe (F), Trp (W), Ile (I), Met (M), Val (V) or Leu (L) residues near the Tyr (Y). |
Absence of disulfide bonds | ±7 | No disulfide-bonded Cys (C) close to the Tyr (Y). |
Absence of N-linked glycosylation sites | N/A | No N-linked glycosylation consensus sequence (N-X-S/T) in vicinity of the Tyr (Y). |
Prevalence of several tyrosine sulfation sites | N/A | Tyr (Y) residues within a tyrosine cluster containing features promoting tyrosine sulfation. |