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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Clonal evolution driven by superdriver mutations

Fig. 2

Traveling Gaussian waves of clonal expansions of superdrivers and drivers in an exponentially growing tumor cell population. a Number of cells with a given configuration of k {0, …, 5} superdriver and {0, …, 10} driver mutations shown by different colors and symbols, respectively. b Same as (a), but on a logarithmic scale. c Subsets of curves of panel (b) with fixed number of either drivers or superdrivers, revealing that tumorigenesis is dominated by superdriver accumulation. While clones with  = 0 drivers have comparable frequency regardless of the number of superdrivers, the frequency of clones with  = 4 drivers increases steeply with the number of superdrivers (upper panel “Fixed driver”). Additional drivers reach only low frequencies (lower panel “Fixed superdriver”) and eventually die out. All cell counts are averages over 50 replicates. For generating this figure, superdriver selection factor was set at c = 2 and driver selection at s = 0.01

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