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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Clonal evolution driven by superdriver mutations

Fig. 3

Change in evolutionary dynamics. a Low superdriver selection allows clones with the same number of superdrivers to exist for a long period of time. Every wave of additional superdriver mutations entails many driver waves with the same number of superdrivers, all of which reach high frequencies. b High superdriver selection changes the dynamics. Every superdriver wave now entails only a few additional drivers of low frequency and superdriver accumulation occurs quicker. All figures display the average frequency of 50 replicates. Superdriver selection was varied at c {1, 1.1, 1.3, 2.6, 2.8, 3}, while driver selection was set to s = 0.01. Only clones with k {0, …, 5} superdriver and {0, …, 10} driver mutations are displayed to facilitate comparison

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