Fig. 4

Subcellular relocalization explains many cases of recurrent sequence evolution. Quartets of specific categories were sampled from all families (see Fig. 3). Besides adhering to one of these categories, quartets are selected if there is significant fate similarity (|Z_F|>1.96) and if there is a reliable prediction of subcellular localization for all four genes (TargetP Reliability Class <3). (Bottom) Fraction of quartets with consistent (green) and inconsistent (orange) subcellular localization patterns (configurations shown at the top). Other patterns are not shown for clarity; 70.8% of Independent Duplication quartets had a uniform localization and 16.7% contained only one gene with a distinct localization. In these cases, the functional change driving recurrent sequence evolution remains unknown. Bars display averages; error bars give standard errors of the proportions; sample sizes are indicated beneath the categories