Fig. 6

Reconciled gene tree of Sco1/Sco2 (see Suppl. Figure S5 for the full gene tree). There are four elements in the alignment that give high support for the Sco1–Sco2 differentiation: two small indels in the mitochondrial target peptide (MTP) and mitochondrial matrix region (MM), and two substitutions in the mitochondrial intermembrane section (MIM) which corresponds to the thioredoxin-like fold. Their colors show with which fate they are associated. For the two substitutions, a specific residue is associated with Sco1 (lysine at position 151 and asparagine at position 276, with human Sco1 as reference), whereas Sco2 is not associated with a specific residue. At the top, the different protein regions are shown (TM: trans-membrane)