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Fig. 4 | BMC Evolutionary Biology

Fig. 4

From: Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Fig. 4

Protein structural deviations in PD associated mutant versions of UCHL1. Major structural shifts caused by disease associated missense mutations of UCHL1 are observed in the secretion signal and farnesylation motifs present in the N-terminal and C-terminal respectively. Deviated residues are labeled in red. a Structure of wild type UCHL1 in which all domains and motifs are color coded. b Structural superimposition of wild type (green) and mutated model E7A (coral peach). c Structural comparison between wild type UCHL1 (green) and mutated model S18Y (coral peach). d Structural deviations among wild type UCHL1 (green) and mutated model I93M (coral peach). e Structural comparison between UCHL1 (green) and mutated model R178Q (coral peach). f Structural superimposition of the wild type (green) and mutated model A216D (coral peach)

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BMC Ecology and Evolution

ISSN: 2730-7182

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