Fig. 5
From: Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance
Alignment of key functional domains in PDX1, INSR, MEDAG, and SPP1 proteins. a Alignment of the conserved PDX1 hexapeptide and homeodomain sequence from representative vertebrates. Gerbil species shown in red; sites where amino acid substitutions are associated with T2D in humans are marked with a star. b Alignment of regions for four domains in the INSR protein. Due to sequence divergence across vertebrates, only sequences from mammals are shown. Gerbil species are shown in red; sites where amino acid substitutions are associated with T2D in humans are marked with a star. c Alignment of a representative region of the MEDAG protein. Gerbil species shown in red. d Alignment of a representative region of the SPP1 protein. Gerbil species are shown in red