Table 1 A list of the sand rat genes that encode the most aberrantly divergent sand rat proteins ordered by ranking, whether these genes are in GC-rich regions, dSws value and a short description of the function of their encoded protein
From: Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance
Rank | Gene | GC-rich region | Sand rat dSws value | Encoded protein |
|---|---|---|---|---|
1 | Pdx1 | Yes | 20.09 | Pancreatic duodenal homeobox. Transcription factor involved in pancreas development and β-cell function. |
2 | Medag | Yes | 3.09 | Mesenteric estrogen dependent adipogenesis. Involved in adipocyte differentiation and glucose uptake. |
3 | Pex11g | Yes | 4.58 | Peroxisomal membrane protein. Involved in growth and division of peroxisomes (organelles partaking in lipid biosynthesis). |
4 | Tex45 | Yes | 1.48 | Testis-expressed protein. Understudied gene expressed in testis. |
5 | Cblc | No | 0.60 | E3 ubiquitin-protein ligase. Involved in protein degradation; down-regulates receptor-tyrosine kinase (RTK) signaling. |
6 | Insr | Yes | 7.08 | Insulin receptor. RTK receptor involved in insulin signaling and stimulation of glucose uptake. |
7 | Trappc5 | Yes | 34.40 | Trafficking protein particle complex subunit. Implicated in vesicular transport from ER to Golgi. |
8 | Pan3 | Yes | 10.66 | Subunit of PAN2-PAN3 deadenylase complex. Trims poly(A) tail prior to degradation. |
9 | B3glct | Yes | 2.29 | Beta 3-glucosyltransferase. Transfers glucose onto fucose on TSR repeat proteins. |
10 | Spp1 | No | 0.22 | Secreted phosphoprotein 1 or osteopontin. Implicated in bone mineralization, immune system, and diet-induced insulin resistance. |