Fig. 3

Pyridoxal phosphate binding site for ornithine decarboxylase along the lineage of Cetacea – A protein homology model of the ancestral protein leading to Cetacea was created. Template for the model was from human ornithine decarboxylase (PDB:2OO0; chain A). Ancestral changes occurring on the lineage for Cetacea have been mapped to the model, sites colored in red indicate nonsynonymous changes in the ancestral protein, sites colored in dark grey are synonymous site changes. The site indicated in green is the pyridoxal phosphate binding site 238. The site adjacent to the binding site is the substitution N238D found on the ancestral lineage. Image was generated from Swiss-PdbViewer