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Fig. 4 | BMC Evolutionary Biology

Fig. 4

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Fig. 4

Active site remodeling for ornithine decarboxylase along the lineage of Cetacea – A protein homology model of the ancestral protein leading to Cetacea was created. Template for the model was from human ornithine decarboxylase (PDB:2OO0; chain A). Ancestral changes occurring on the lineage for Cetacea have been mapped to the model, sites colored in red indicate nonsynonymous changes in the ancestral protein, sites colored in dark grey are synonymous site changes. The site indicated in gold is the active site cysteine-357. Remodeling of the active site can be seen in the changes P368Q, R375C, I376M, and R379H which are positioned around the loop containing the active site

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